Huahana

ʻO Tulathromycin, he lāʻau antibacterial ākea ākea me ka hana antibacterial e kū'ē i kekahi mau hua bacteria gram-positive a me Gram-negative.He mea maʻalahi ia i nā pathogens o nā maʻi hanu i loko o nā pipi a me nā puaʻa, e like me Actinobacillus pleuropneumoniae, Pasteurella haemolyticus, Pasteurella haemorrhagica, histophilus hiamoe (Haemophilus hiamoe), Mycoplasma pneumoniae, Haemophilus parasuis, Bordetella bronchiseptica, etc.

ʻO nā hiʻohiʻona pharmacokinetic o Tulathromycin ʻo ia ma hope o ka hoʻohana ʻana i hoʻokahi dosis, e hoʻopili koke ʻia i ka wahi i hoʻopaʻa ʻia, mālama ʻia ke kahe koko kūpono no ka manawa lōʻihi, lohi ka hoʻopau ʻana, nui ka nui o ka hāʻawi ʻana, kiʻekiʻe ka bioavailability. ʻoi aku ka kiʻekiʻe o ka ʻike i loko o ka ʻiʻo peripheral ma mua o ka plasma.ʻO ka hāʻawi ʻana i ka ʻiʻo nui a me ka permeability cell maikaʻi nā hiʻohiʻona koʻikoʻi o ka metabolism Tulathromycin.ʻO ka hōʻiliʻili ʻana i nā cell immune kekahi mea nui o Tulathromycin.

Kāohi ʻo Tulathromycin i ka synthesis protein bacterial ma ke kāohi ʻana i ke kaʻina hoʻoili peptide bacterial.Ma muli o kekahi mau hemahema koʻikoʻi o ka erythromycin, pono nā kānaka i kahi lāʻau ʻē aʻe ma mua o ka erythromycin me ka wikiwiki.ʻO Tulathromycin kahi ʻano hou o ka macrolide semi synthetic antibiotic no nā holoholona.He nui kona mau pono, e like me ka haʻahaʻa haʻahaʻa, hoʻokahi manawa hoʻokele, haʻahaʻa koena, holoholona kikoʻī a pēlā aku.ʻAʻole wale ia i nā pōmaikaʻi o nā lāʻau lapaʻau macrolide, akā loaʻa pū kekahi i ka hapalua lōʻihi lōʻihi i ʻoi aku ka maikaʻi ma mua o nā lāʻau antibiotic macrolide.Ma muli o ka pono o ka mālama ʻana i ka hoʻomaʻamaʻa therapeutic kūpono i ke kino no ka manawa lōʻihi, hiki iā ia ke hoʻokō i ka bacteriostasis maikaʻi a me ka sterilization.

Ma hope o ka hoʻohana nui ʻana i ka lāʻau lapaʻau, loaʻa ka tulathromycin i ka hopena therapeutic i nā maʻi hanu o nā pipi a me nā puaʻa.Mahalo no ka hana antibacterial maikaʻi loa o Tulathromycin e like me ka hoʻohana ʻana i nā mea liʻiliʻi, ka hapalua o ke ola a me ka hoʻokele hoʻokahi manawa, hiki ke hoʻohana ākea.

ʻOi aku ka ikaika o Tulathromycin ma mua o nā macrolides i hoʻohana nui ʻia i ka mākeke i kēia manawa, e like me tylosin, tilmicosin a me florfenicol.Loaʻa iā ia nā noi nui loa.

E hoʻomanaʻo ʻia ʻo Tulathromycin kahi palekana, ʻaʻohe carcinogenicity, teratogenicity a me genotoxicity.ʻAʻole ia e hoʻoulu i ka mutation gene, akā hiki ke hana i ka cardiotoxicity.Pono e hahai i ka ʻōlelo aʻoaʻo o ka veterinary.