Tacrolimus monohydrate 109581-93-3 Antibiotic
Uku:T/T, L/C
Kumu Huahana:Kina
Awa moku:Pekina/Shanghai/Hangzhou
Hiki ke hana:1kg / mahina
Kauoha(MOQ):1g
Ka manawa o waena o ka hoʻomaka a i ka wā pau:3 Nā lā hana
Kūlana mālama:Hoʻopaʻa ʻia ma kahi anuanu, maloʻo, ka lumi wela.
Mea paʻa:hue, ʻōmole
Nui pūʻolo:1g/puʻu, 5/puʻu, 10g/puʻu, 50g/puʻu, 500g/puʻu
ʻIke palekana:UN 2811 6.1/PG 3
Hoʻolauna
ʻO Tacrolimus, kahi lāʻau immunosuppressive.Ma hope o ka hoʻololi ʻana o ke kino allogeneic, ʻoi aku ka maʻalahi o ka hōʻole ʻana o ke kino.No ka hoʻohaʻahaʻa i ka hopena o ka hōʻole ʻana o ke kino, hāʻawi ʻia ka tacrolimus.Hiki ke kūʻai ʻia ka lāʻau lapaʻau ma ke ʻano he lāʻau lapaʻau i ka mālama ʻana i nā maʻi T-cell-mediated e like me ka eczema a me psoriasis.Hiki ke hoʻohana ʻia e mālama i ka maʻi maloʻo o ka maka i nā pōpoki a me nā ʻīlio.
Kāohi ʻo Tacrolimus i ka calcineurin, ka mea i komo i ka hana ʻana o ka interleukin-2, he mole e hoʻoikaika i ka hoʻomohala ʻana a me ka hoʻonui ʻana o nā pūnae T, ma ke ʻano he ʻāpana o ke kino i aʻo ʻia (a i ʻole adaptive).
Hōʻike (USP43)
| 'ikamu | Hōʻike |
| Ka nana aku | Keʻokeʻo a ʻaneʻane keʻokeʻo crystalline pauda |
| ʻIkepili | IR, HPLC |
| Ka hoʻoheheʻe | Hiki ke hoʻoheheʻe ʻia i ka methanol, hiki ke hoʻoheheʻe ʻia i ka N,N dimethylformamide a me ka waiʻona, hiki ke hoʻoheheʻe ʻia i ka wai. |
| Ke koena ma ka ʻā | ≤0.10 % |
| ʻO nā mea haumia kino (ka hana-2) | Ascomycin 19-epimer ≤0.10 % |
| Ascomycin ≤0.50 % | |
| Desmethyl tacrolimus ≤0.10 % | |
| Tacrolimus 8-epimer ≤0.15 % | |
| Tacrolimus 8-propyl analog ≤0.15 % | |
| He haumia ʻike ʻole -I ≤0.10 % | |
| He haumia ʻike ʻole -II ≤0.10 % | |
| He haumia ʻike ʻole -III ≤0.10 % | |
| Huina haumia ≤1.00 % | |
| ʻO ka hoʻololi ʻana (ma ke ʻano he kumu) (10mg/ml i ka N,Ndimethylformamide) | -110.0° ~ -115.0° |
| Waiwai (na KF) | ≤4.0% |
| Nā mea hoʻoheheʻe koena (na GC) | Acetone ≤1000ppm (Ma ka hale) |
| Di-isopropyl ether ≤100ppm (Ma ka hale) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| ʻO ka hoʻāʻo microbial (ma ka hale) | Ka huina aerobic microbial helu ≤100cfu/gm |
| Huina hū a me ka helu helu ≤10cfu/gm | |
| Pono ʻole nā mea ola kino (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) | |
| ʻIke (e HPLC) (ma ke kumu anhydrous a me ka solvent free) | 98%~102% |
